A Real Multitechnology Microgrid in Venice: A Design Review

Electrical grids are evolving rapidly toward smart, self-regulating systems capable of managing distributed generation from intermittent renewable sources. Apart from hydroelectric, the large majority of them are photovoltaic (PV) systems grasping the fluctuating solar radiation and wind turbines (WT) capturing fickle wind energy, but other sources, which are at different stages of development, also generate energy with predictable or unpredictable intermittency. Several investigations have highlighted that, when power production from intermittent sources exceeds 20% of the total generation, the grid may face instabilities that can evolve into blackouts. Energy storage (ES) is a measure to balance source-load mismatches and to avoid such occurrence, but it can also provide a number of additional services which are part of the smart-grid paradigm. The operation of energy storage systems (ESSs) depends on the interface converters that manage the power flow and on the supervisors that control them according to the ESS, grid, and load features. Furthermore, the transmission system operator (TSO) may impose constraints on the ESS operation such as the obligation of contributing to primary regulation. Several numerical analyses have been developed to investigate the behavior of electrical grids provided with energy generation from renewable sources and energy storage, either islanded or connected to the national/transnational grid (macrogrid)

Improving flexibility of industrial microgrids through thermal storage and HVAC management strategies

Abstract The increasing share of non-programmable renewable energy sources in national energy portfolios requires a high flexibility to balance demand and offer in energy markets. Demand side management programs and microgrids will play a key role in achieving flexibility on the demand side. This paper aims at presenting the increase of flexibility that can be achieved by an industrial microgrid. On field tests were carried out in an Italian industrial microgrid, where a set of load management strategies were implemented. These strategies aim at leveraging the thermal inertia of a building using both thermal energy storage and the HVAC system. Results show that the thermal energy storage can contribute to limit the peak cooling load by up to 40 kWe for three hours, while implementing a load shifting strategy using the HVAC system can provide a temporary reduction in power consumption of 20 kWe. Results also prove that it is possible to identify the effect of a load shifting strategy using electricity consumption data sampled with a 15-minutes granularity

Outdoor activity: orienteering, one step towards an advanced scientific evaluation of game determinants using latest dedicated technologies combined with literature review

The purpose of the researches of the ARGS group (Advanced Research Group in Sport) is to try to create specific scientific work parameters obtained with objective means, to better qualify and quantify the performance descriptors of orienteering, in this case, to better define the physiological model, an essential element to outline the real needs for a safe and performative practice,for all types of participants.It would be a mistake, in our opinion, to evaluate orienteering as a recreational activity, simple and free of risks for individual health since it is a competitive game substantially based on speed and its components such as accelerations, decelerations, changes in run speed, and direction. Moreover, the cognitive commitment is crucial, such as those deriving from the reading and analysis of topographic maps to find the points defined as "lanterns" and thus reach the finish line in the shortest possible time.However, a sport that, although nominally known by everyone, is often considered just a walk over the mountains or a recreational treasure hunt, with all the benefits that these activities still bring with them, but therefore not considered with those values that are instead in is own and that certainly insert it as a real motor-sport activity with an important additional element in addition to the location (usually the natural environment), that is the not excessive competitive charge. This investigation analysis has, in the end, the aim to define a proper way to identify the physiological and physical request of the sport and to the extent the application of advanced technology to orienteering and evaluate the possible benefits of using them. The expected result is, therefore, to elaborate parameters on the real consistency of the external load in relation to the internal one caused by orienteering, which can then be applied in its various modalities and different individuals, helping them to avoid traumas and injures too, using the latest generation of wearable devices and therefore without creating discomfort

La donazione del sangue come prassi sociale. Scenario per AVIS al 2027

Gli studi di scenario planning costituiscono ormai da circa quindici anni un’importante risorsa del CNR-Irpps. L’innovativa metodologia Delphi sviluppata dall’Istituto e perfezionata nel tempo dal curatore di questo paper ha avuto numerose applicazioni in campo nazionale e internazionale, e su tematiche diverse che hanno riguardato aspetti sociali, culturali, demografici e sanitari della popolazione. Il paper presenta i risultati di uno studio Delphi in tema di donazione di sangue in Italia. Il lavoro, commissionato nel 2016 all’Istituto dall’Associazione Volontari Italiani del Sangue (AVIS), ha coinvolto i concetti di dono e di volontariato, che sotto il profilo socio-culturale costituiscono le matrici di senso dell’atto della donazione di sangue, delineando strategie comunicative e organizzative che potranno rafforzare nel corso dei prossimi dieci anni la pratica della donazione in Italia. Si apre così la strada a uno scenario futuro innovativo, in cui il concetto di dono diviene sinonimo di benessere, integrazione sociale, socializzazione

Performance improvement in yo-yo intermittent recovery test Level 2 and during official matches: The role of speed endurance training production in Élite football players

This study aims to examine the performance improvement in yo-yo intermittent recovery test level 2 (IR2) and official matches, during a competitive season in professional football players (Italian 3rd Division Series C, 2019- 2020). Twenty-eight (n=28) élite football players participated in this study (age 21.4±3.3; body weight 79.7±3.4; height 182.4±5.5; fat mass 9.2±1.9), without goalkeepers. In the pre-season (4 weeks, from July to August), the players performed yo-yo intermittent recovery test level 2 (IR2), to evaluate aerobic and anaerobic performance before the start of the season. Every player has been analysed with a K-GPS Live device 50Hz (K-Sport Universal STATS, Italy) and Polar Team System PRO 2 heart-rate sensor (Polar Electro, Finland) to recorder maximal heart rate. After 12 weeks of training (in season), the same players repeat an IR2 test to check performance improvements and verify whether the training programme is correct. The first element was to determine whether the improvement in distance covered during a test is better, the same, or worse with respect to the pre-season. After 12 weeks of training, the difference between the first trial (pre-season) and the second one (in-season) is statistically significant (ES: 0.48; p<0.05; 24%). At the same time, there has been a significant improvement in match physical performance. Regarding the importance of speed endurance training during a season, it is necessary to improve performance in IR2 test after 12 weeks and improve maximal oxygen uptake and glycolytic enzyme activity. Comparing match performance before (T1) the second trial IR2 with match performance after second (T2) trial of this test, there are statistically meaningful changes

Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells.

Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored approach in the clinical management of patients. Nerve growth factor, initially identified as a key factor for neuronal survival and differentiation, turned out to be a multifaceted molecule with pleiotropic effects in quite divergent cell types, including cancer cells. Many solid tumors exhibit derangements of the nerve growth factor and its receptors, including the tropomyosin receptor kinase A. This receptor is expressed in triple-negative breast cancer, although its role in the pathogenesis and aggressiveness of this disease is still under investigation. We now report that triple-negative breast cancer-derived MDAMB- 231 and MDA-MB-453 cells express appreciable levels of tropomyosin receptor kinase A and release a biologically active nerve growth factor. Activation of tropomyosin receptor kinase by nerve growth factor treatment positively affects the migration, invasion, and proliferation of triple-negative breast cancer cells. An increase in the size of triple-negative breast cancer cell spheroids is also detected. This latter effect might occur through the nerve growth factor-induced release of matrix metalloproteinase 9, which contributes to the reorganization of the extracellular matrix and cell invasiveness. The tropomyosin receptor kinase A inhibitor GW441756 reverses all these responses. Co-immunoprecipitation experiments in both cell lines show that nerve growth factor triggers the assembly of the TrkA/b1-integrin/FAK/Src complex, thereby activating several downstream effectors. GW441756 prevents the complex assembly induced by nerve growth factor as well as the activation of its dependent signaling. Pharmacological inhibition of the tyrosine kinases Src and FAK (focal adhesion kinase), together with the silencing of b1-integrin, shows that the tyrosine kinases impinge on both proliferation and motility, while b1-integrin is needed for motility induced by nerve growth factor in triple-negative breast cancer cells. The present data support the key role of the nerve growth factor/tropomyosin receptor kinase A pathway in triple-negative breast cancer and offer new hints in the diagnostic and therapeutic management of patients

Definition of physical-dynamic parameters in circular kick in Muay Thai through latest generation inertial sensors with a critical review of the literature

In recent years, the study of movement analysis with the application of dedicated advanced technologies, such as inertial technologies, has also become essential in scientific research of sports disciplines such as martial arts and combat sports, to better define the real dynamics of technical components in order to adapt the training design. A great number of studies in the literature have focused on the kinematics of circular kick in combat sport and martial arts but a relatively small number have focused on the kinetic and kinematic analysis of Muay Thai and especially its circular kick technique. This study aims to highlight instrumentally the quality of circular kick gesture and through which segmental motor dynamics it achieves its greatest effectiveness, evaluating the accelerations and execution times of the different body segments involved in technical execution itself obviously in a performative sense. It is important to note that the inertial data shows that both knee and ankle have an increasing linear velocity greater than the hip in the preparation and execution phase, while for the angular velocity in the execution phase it is the hip that has higher acceleration than the knee and ankle. These results, therefore, highlight the basic importance of intra-articular and intramuscular coordination processes that allow or not linearity and fluidity of movements that are the basis to obtain maximum intersegmental performance in order to deliver maximum acceleration in the apical point of the shot and thus have the maximum effectiveness of hit and therefore the optimal performance

Sunscreens Cause Coral Bleaching by Promoting Viral Infections

Background: Coral bleaching (i.e., the release of coral symbiotic zooxanthellae) has negative impacts on biodiversity and functioning of reef ecosystems and their production of goods and services. This increasing world-wide phenomenon is associated with temperature anomalies, high irradiance, pollution, and bacterial diseases. Recently, it has been demonstrated that personal can products, including sunscreens, have an impact on aquatic organisms similar to that of other contaminants. Objectives: Our goal was to evaluate the potential impact of sunscreen ingredients on hard corals and their symbiotic algae. Methods: In situ and laboratory experiments were conducted in several tropical regions (the Atlantic, Indian, and Pacific Oceans, and the Red Sea) by supplementing coral branches with aliquots of sunscreens and common ultraviolet filters contained in sunscreen formula. Zooxanthellae were checked for viral infection by epifluorescence and transmission electron microscopy analyses. Results: Sunscreens cause the rapid and complete bleaching of hard corals, even at extremely low concentrations. The effect of sunscreens is due to organic ultraviolet filters, which are able to induce the lyric viral cycle in symbiotic zooxanthellae with latent infections. Conclusions: We conclude that sunscreens, by promoting viral infection, potentially play an important role in coral bleaching in areas prone to high levels of recreational use by humans

Correlation between Chest Computed Tomography Score and Laboratory Biomarkers in the Risk Stratification of COVID-19 Patients Admitted to the Emergency Department

background: it has been reported that mid-regional proadrenomedullin (MR-proADM) could be considered a useful tool to stratify the mortality risk in COVID-19 patients upon admission to the emergency department (ED). during the COVID-19 outbreak, computed tomography (CT) scans were widely used for their excellent sensitivity in diagnosing pneumonia associated with SARS-CoV-2 infection. however, the possible role of CT score in the risk stratification of COVID-19 patients upon admission to the ED is still unclear. aim: the main objective of this study was to assess if the association of the CT findings alone or together with MR-proADM results could ameliorate the prediction of in-hospital mortality of COVID-19 patients at the triage. moreover, the hypothesis that CT score and MR-proADM levels together could play a key role in predicting the correct clinical setting for these patients was also evaluated. methods: epidemiological, demographic, clinical, laboratory, and outcome data were assessed and analyzed from 265 consecutive patients admitted to the triage of the ED with a SARS-CoV-2 infection. results and conclusions: the accuracy results by AUROC analysis and statistical analysis demonstrated that CT score is particularly effective, when utilized together with the MR-proADM level, in the risk stratification of COVID-19 patients admitted to the ED, thus helping the decision-making process of emergency physicians and optimizing the hospital resources